The Arthur lab has open positions for postdocs and graduate students!
Postdocs, please send your cover letter and CV to ArthurLabUNC@gmail.com
The Arthur Lab investigates microbiome-mediated mechanisms driving intestinal inflammation and inflammation-associated co-morbidities such as cancer and fibrosis.
Crohn's Disease & Fibrosis
Many patients with Crohn’s Disease experience fibrotic stricturing in their intestines, which can damage the colon and worsen disease. The Arthur Lab uses the IL10-/- colitis model and bacterial mono-association to study the role of microbial small molecules in IBD-associated fibrosis. We have developed a unique model which resembles human intestinal fibrosis, which we use to study the mechanism and resolution of the disease. We use a wide variety of techniques including in vivo and in vitro models, biochemistry, immunofluorescence, and bioinformatics.
Dynamic Microbial Communities in Colitis
The gut microbial community changes in response to inflammation with some species, such as E. coli, blooming in this environment. To study how the populations of multiple microbial strains shift in response to different environments in the gut, we use a DNA barcoding technique to allow us to quantify genetically similar microbes in a complex community. We apply this technology to study mucosal microbial colonization in a colitis model, and can further use the barcoding technique for spatial visualization of microbes in the gut.
The Arthur lab uses the National Gnotobiotic Rodent Resource Center (clink here to learn more)